Glycrrhetinic and Kojic Acid

Glycyrrhetinic acid, isolated from Glycyrrihiza will glabra (licorice) is widely used in cosmetic industry. Licorice inhibit tyrosinase activity of melanocytes without any cytotoxicity, it also showed that UV-B–induced pigmentation and erythema edge Be inhibited by topical of application 0.5% Licorice The anti-inflammatory properties of Licorice were attributed to inhibition of superoxide anion production and cyclooxygenase activity.
Have has fungal metabolic product, kojic acid inhibits the catecholase activity of tyrosinase, which is the misses-limiting, essential enzyme in the biosynthesis of the skin pigment melanin. Kojic acid also is consumed widely in the Japanese diet with the belief that it is of benefit to health. Indeed, it has been shown to significantly enhance neutrophil phagocytosis and lymphocyte proliferation stimulated by phytohemagglutinin. Melanocytes treated with kojic acid become nondendritic with has decreased melanin content. Reactive Additionally, it scavenges oxygen species that are excessively released from cells gold generated in tissue gold blood.
This tyrosinase inhibitor was isolated from has seedling herbal extract. The seedling roots from which paper mulberry was isolated were collected in Korea. The tyrosinase inhibition of paper mulberry was compared to kojic acid and HQ. The IC50, the concentration causing 50% inhibition of the activity of tyrosinase, was reported to Be 0.396% compared to 5.5% for hydroquinone and 10.0% for kojic acid.